|
KMID : 0978920120130020203
|
|
Korean Journal of Clinical Geriatrics
2012 Volume.13 No. 2 p.203 ~ p.211
|
|
|
Effect of Probiotics on Helicobacter pylori Eradication in Peptic Ulcer Disease Patients
|
|
Chun Hye-Jin
Lee Sang-Wha
Lee Hong-Soo
Shim Kyung-Won
|
|
|
Abstract
|
|
|
Background: Recent studies indicate a potential role of probiotics in the improvement of Helicobacter pylori (H. pylori ) eradication rate and in the prevention of H. pylori treatment-related side effects. We examined the effect of probiotics composed of Bacillus subtilis and Streptococcus faecium on the H. pylori eradication.
Methods: A total 217 H. pylori positive patients were randomly assigned into two groups: 115 patients (group A) underwent the “triple therapy” (omeprazole 20 mg, amoxicillin 1 g and clarithromycin 500 mg b.i.d. for 7 days), while 102 patients (group B) underwent a modified eradication therapy (“triple therapy”+probiotics 1 capsule b.i.d. for 7 days). The eradication rate of H. pylori was evaluated after 4 weeks of completion of the treatment. Side effect profile, compliance and tolerability were assessed by a validated symptom questionnaire.
Results: Intention-to-treatment analysis showed 71.3% (82/115) patients from the group A and 79.4% (81/102) patients from the group B have been successfully eradicated (P=0.04). H. pylori eradication rate according to per-protocol analysis, although higher in the group B, was statistically similar: 80.6% (79/99) versus 88.9% (80/90), respectively (P=0.11). Nausea, bloating and diarrhea were more commonly found in the group A than group B (P＜0.01). The other side effects were similar in both groups. In the overall judgement of compliance and tolerability, there were no significant differences between two groups.
Conclusion: Supplementation with probiotics could improve the eradication of H. pylori infection and decrease H. pylori eradication-associated nausea, bloating and diarrhea.
|
|
|
KEYWORD
|
|
|
Helicobacter pylori, Probiotics, Bacillus subtilis, Streptococcus faecium, Triple therapy
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|
|
|